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Artigos e Estudos Médicos

Leukoencephalopathies in childhood

Awareness of cerebral white matter disorders has markedly increased since the introduction of magnetic resonance imaging (MRI). Although MRI is very sensitive in showing white matter signal abnormalities, the etiology of these changes often remains unknown. During the last decade, several new leukoencephalopathies have been delineated based on characteristic patterns of MRI changes for each of them. Recently, the genetic basis of some of these disorders has been elucidated. However, more than half of children with white matter abnormalities on brain MRI still have no specific diagnosis...

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